0516最新英文科普 打字学习同步
One of the great promises of stem-cell biology is to use a
patient's own cells as a template to build a real, working
organ or tissue in the lab. One prime example: a treatment
fordiabetes by turning stem cells into working pancreatic
beta cells, which release insulin.
"The existing beta cells that our lab and others had created
were 90 percent of the way there. But 90 percent still means
not functional." Ron Evans, a molecular biologist at the Salk
Institute.
Evans compares the stem-cell-derived beta cells they first
made to a darkened room. "If you walk into that room, there
may be everything in it that you need to be a complete room,
with furniture and chairs and everything else. But it's dark.
And the key is: what do you need to turn on the light?"
That light switch, Evans discovered, is a gene-called estrogen-
related receptor gamma. Flip it on, and it activates a genetic
circuit that ramps up mitochondria production, powers up the
cell, and endows the almost-functional beta cells with the
ability to sense glucose and release insulin in response.
Evans's team recently used that trick to transform stem cells
into beta cells that worked just like they would in a healthy
pancreas. When they transplanted those cells into mice with a
mouse version of diabetes, blood glucose fell to normal levels
in half the rodents. The results are in the journal Cell
Metabolism. [Eiji Yoshihara et al, ERR gama Is Required for the
Metabolic Maturation of Therapeutically Functional Glucose-
Responsive beta Cells]
Next, Evans says he'll replicate the test in diabetic primates.
"Primates get diabetes in a fashion that's very similar to people.
So if it works in a primate, very high probability that it's
going to work in people." If it does, we might someday replace
a shot of insulin with a shot of cells.
patient's own cells as a template to build a real, working
organ or tissue in the lab. One prime example: a treatment
fordiabetes by turning stem cells into working pancreatic
beta cells, which release insulin.
"The existing beta cells that our lab and others had created
were 90 percent of the way there. But 90 percent still means
not functional." Ron Evans, a molecular biologist at the Salk
Institute.
Evans compares the stem-cell-derived beta cells they first
made to a darkened room. "If you walk into that room, there
may be everything in it that you need to be a complete room,
with furniture and chairs and everything else. But it's dark.
And the key is: what do you need to turn on the light?"
That light switch, Evans discovered, is a gene-called estrogen-
related receptor gamma. Flip it on, and it activates a genetic
circuit that ramps up mitochondria production, powers up the
cell, and endows the almost-functional beta cells with the
ability to sense glucose and release insulin in response.
Evans's team recently used that trick to transform stem cells
into beta cells that worked just like they would in a healthy
pancreas. When they transplanted those cells into mice with a
mouse version of diabetes, blood glucose fell to normal levels
in half the rodents. The results are in the journal Cell
Metabolism. [Eiji Yoshihara et al, ERR gama Is Required for the
Metabolic Maturation of Therapeutically Functional Glucose-
Responsive beta Cells]
Next, Evans says he'll replicate the test in diabetic primates.
"Primates get diabetes in a fashion that's very similar to people.
So if it works in a primate, very high probability that it's
going to work in people." If it does, we might someday replace
a shot of insulin with a shot of cells.
上一篇:VR(虚拟现实技术)
下一篇:行为主义和人本主义
声明:以上文章均为用户自行添加,仅供打字交流使用,不代表本站观点,本站不承担任何法律责任,特此声明!如果有侵犯到您的权利,请及时联系我们删除。
文章热度:★☆☆☆☆
文章难度:☆☆☆☆☆
文章质量:★☆☆☆☆
说明:系统根据文章的热度、难度、质量自动认证,已认证的文章将参与打字排名!
本文打字排名TOP20
- 1游客13420036... 05-19 15:03312 KPM
- 2游客13430762... 05-19 15:58302 KPM
- 3游客13075215... 05-19 15:43298 KPM
- 4满庭芳 05-18 20:59296 KPM
- 5游客13609556... 05-19 16:07271 KPM
- 6游客13536309... 05-18 18:24263 KPM
- 7游客13608019... 05-18 21:30254 KPM
- 8油菜想见阎奕... 05-18 18:10243 KPM
- 9VicTaylor 05-18 16:36236 KPM
- 10游客13586485... 05-18 17:07225 KPM
- 11游客13558981... 05-18 17:36220 KPM
- 12學航 05-18 16:14197 KPM
- 13冲出新手村 05-18 18:12194 KPM
- 14人间有别愁 05-18 22:08186 KPM
- 15游客13429681... 05-18 16:44168 KPM
- 16游客12972239... 05-18 23:11162 KPM
- 17下雨天遇到鬼 05-19 09:54156 KPM
- 18宇宙无敌天才 05-18 16:25146 KPM
- 19游客13528216... 05-18 16:30145 KPM
- 20游客13603134... 05-18 16:35142 KPM
用户更多文章推荐
- 这个简单的练习就能提升自控力2020-07-15
- 脱水还会让你又傻又暴躁?2020-07-12
- 充电器究竟一年能产多少热?2020-07-11
- Pharaohs Got Yummy Mummy Me...2020-07-05
- 寄生虫让我们拥有了“性”?2020-07-02
- 醉酒能提高存活率?2020-06-22
- 植物也有“裙带关系”?2020-06-21
- 肺也能“尝”到气味2020-06-20
- 换换盘子颜色也能让我们吃的更少2020-06-18
- 明星找对象,也会看学历2020-06-17
- 发朋友圈的快乐和挣钱一样2020-06-14
- 护士人手不够增加患者的死亡风险2020-06-06
- 坐着不动在速配约会里更具吸引力2020-06-05
- 0602最新英文科普 打字学习同步2020-06-02
- 0601最新英文科普 打字学习同步2020-06-01
- 0531最新英文科普 打字学习同步2020-05-31
- 0527最新英文科普 打字学习同步2020-05-27
- 0526最新英文科普 打字学习同步2020-05-26
- 0519最新英文科普 打字学习同步2020-05-19
- 0518最新英文科普 打字学习同步2020-05-18
- 0517最新英文科普 打字学习同步2020-05-17